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Clinical Trial 4

Anti-carcinogen effect of Plantbiotic lactic-acid products and its active component BIOSTIM with various Lactobacillus Bulgaricus strains

A nutritional regimen with four types of lactic-acid products containing different Lactobacillus Bulgaricus strains have been administered to rats with dimethylhydrazine (DMH) -induced tumor within a 7-month experiment.

The following results were observed:

* All four lactic-acid products led to a reduction of DMH-induced tumor incidence by 81.8% in group 0 and by 50% in groups 1,2,3,4.
* The average number of tumors per animal varied among the four groups and in all cases was lower than that in the controls, which were treated with DMH and given only briquette vivarium food.
* In all experimental groups fed with lactic acid food, the percentage of malignancies was lower than that in the controls. Also, the percentage of animals exhibiting induced malignant growth was lower.
* Histology showed a prevalence of adenocarcinoma observed with the control group where, as well as in the group of the experimental animals fed with lactic-acid products no benign tumors were observed.
* A marked difference in the anti-carcinogenic properties was observed with the different Lactobacillus Bulgaricus strains. Animals treated with strains that produce D-negative lactic acid exhibited the lowest percentage of tumor growth, the lower average number of tumors per animal, and the highest percentage of benign tumors. Experimental animals fed with Lactobacillus Bulgaricus producing mainly L-positive lactic acid experienced a weaker anti-carcinogenic effect.

The experiment confirms the results obtained by I. Bogdanov, some Japanese researchers (A. Hosono et al.) and other investigators of the anti-carcinogenic effect of lactic-acid products and especially those containing Lactobacillus Bulgaricus.

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